Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal, therefore they are considered as a highly promising stem cell population for the tissue engineering. MSCs are identified in various adult
organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSCs population and many researchers have isolated them and performed their detailed characterization. Here, we review the current
understanding of the features and functions of MSCs population in PDL tissues and discuss their possibility for the application of PDL regeneration.
Author(s) Details
Atsushi Tomokiyo
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.
Shinichiro Yoshida
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.
Sayuri Hamano
Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan and OBT Research Center, Kyushu University, Fukuoka, Japan.
Daigaku Hasegawa
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.
Hideki Sugii
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan.
Hidefumi Maeda
Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan and Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
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