Clavulanic acid enhances the antibacterial spectrum of amoxicillin by rendering most β-lactamase-producing isolates susceptible to the drug. In clinical trials amoxicillin/clavulanic acid is clinically and bacteriologically superior to amoxicillin alone and at least as effective as numerous other comparative agents, such as orally administered cephalosporins, cotrimoxazole, doxycycline and bacampicillin, in the treatment of adults and children with the most common forms of infection encountered in general practice, i.e. urinary tract infections, upper and lower respiratory tract infections, otorhinolaryngological infections, and skin and soft tissue infections. It may also provide effective treatment for uncomplicated gonorrhoea, chancroid and gynaecological infections as well as acting as a prophylactic agent against surgical infection. 
Antibiotic removal from wastewaters: The ozonation of amoxicillin
The presence of amoxicillin, a widely used antibiotic, has been documented in Sewage Treatment Plant (STP) effluents. As for other pharmaceuticals, ozonation is proposed as a process for its abatement from these effluents. The results of ozonation experiments on amoxicillin-containing aqueous solutions indicate that ozone attack is mainly directed towards the phenolic ring of the studied molecule leading to the formation of hydroxyderivative intermediates. No direct evidences of attack on sulfur atom with sulfoxide formation are found. A kinetic investigation is carried out allowing the assessment of the kinetics of direct ozone attack and that of OH radicals to amoxicillin.
In Vivo Activities of Amoxicillin and Amoxicillin-Clavulanate against Streptococcus pneumoniae: Application to Breakpoint Determinations
The in vivo activities of amoxicillin and amoxicillin-clavulanate against 17 strains of Streptococcus pneumoniae with penicillin MICs of 0.12–8.0 mg/liter were assessed in a cyclophosphamide-induced neutropenic murine thigh infection model. Renal impairment was produced by administration of uranyl nitrate to prolong the amoxicillin half-life in the mice from 21 to 65 min, simulating human pharmacokinetics. 
Studies on the Removal of Amoxicillin by Single Walled Carbon Nanotubes
The research was conducted to determine effectiveness of CNTs as sorbents for removal of AMO from aqueous solution and to analyze the impact of various parameters including adsorbent dosage, initial Amoxicillin concentration, contact time and temperature on the adsorption capacity of CNTs. The percentage of AMO removal decreased with increase in initial concentration. Adsorption equilibrium of AMO removal was observed after 45 min of contact time. Maximum AMO removal efficiency was obtained to be 99.1% and best results were achieved in contact time of 45 min, adsorbent dosage of 0.3 g/l, initial AMO concentration of 200 mg/l and temperature equal with 323 K. Equilibrium data were fitted to Langmuir and Freundlich isotherms, and their constants were determined. Using the linear correlation coefficients showed that the Langmuir isotherm best fits the AMO adsorption data on SWCNTs. The experimental data were fitted into the following kinetic 
Thermodynamic Analysis for Adsorption of Amoxicillin onto Magnetic Carbon Nanotubes
The effect of temperature on the equilibrium adsorption of Amoxicillin (AMO) from aqueous solution using modified magnetic multi-walled carbon nanotubes (MMWCNTS) was investigated. The equilibrium adsorption data were analyzed using three widely applied isotherms: Langmuir, Freundlich and Tempkin. The results revealed that Langmuir isotherm fit the experimental results well. Kinetic analyses were conducted using pseudo-first and second-order models and the intraparticle diffusion model. The regression results showed that the adsorption kinetics were more accurately represented by pseudo-second-order model. Standard free energy changes (△G0), standard enthalpy change (△H0), and standard entropy change (△S0) were calculated at different temperatures. The △G0 values were negative and △H0 values and △S0 values of MMWCNTS were positive; and suggested that the AMO adsorption on MMWCNTS was a spontaneous and endothermic process. 
 Todd, P.A. and Benfield, P., 1990. Amoxicillin/clavulanic acid. Drugs, 39(2), pp.264-307.
 Andreozzi, R., Canterino, M., Marotta, R. and Paxeus, N., 2005. Antibiotic removal from wastewaters: the ozonation of amoxicillin. Journal of hazardous Materials, 122(3), pp.243-250.
 Andes, D. and Craig, W.A., 1998. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrobial agents and chemotherapy, 42(9), pp.2375-2379.
 Balarak, D., Mahdavi, Y., Maleki, A., Daraei, H. and Sadeghi, S., 2016. Studies on the removal of amoxicillin by single walled carbon nanotubes. Journal of Pharmaceutical Research International, pp.1-9.
 Balarak, D., Mostafapour, F.K. and Joghtaei, A., 2017. Thermodynamic analysis for adsorption of amoxicillin onto magnetic carbon nanotubes. Journal of Pharmaceutical Research International, pp.1-11.