The diagnosis of iron deficiency anemia
Studies during a group of patients with iron deficiency anemia indicate that 16 per cent saturation of plasma transferrin or less implies an inadequate supply of iron to the erythroid marrow and is associated in time with hypochromic, microcytic anaemia . In some patients with infection similar depressions in transferrin saturation were observed, and these were also related to a decrease in red cell hemoglobin. it’s further documented that decreased erythropoiesis, thanks to an inadequate iron supply, isn’t immediately related to changes in cell indices which an inadequate supply of iron to the individual cell has no reference to the entire amount of blood being produced. 
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout mice. In these mice, as in murine models of hemochromatosis and patients with hereditary hemochromatosis, iron accumulates in parenchymal cells (in particular, liver and pancreas), whereas the RES is spared from this iron loading. We suggested that this phenotypic trait might be attributed to the absence, within the Usf2 knockout mice, of a secreted liver-specific peptide, hepcidin. We conjectured that the reverse situation, namely overexpression of hepcidin, might end in phenotypic traits of iron deficiency. This question was addressed by generating transgenic mice expressing hepcidin under the control of the liver-specific transthyretin promoter. We found that the bulk of the transgenic mice were born with a pale skin and died within a couple of hours after birth. 
Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia
Recent studies have shown that the serum transferrin receptor may be a sensitive, quantitative measure of tissue iron deficiency. This study was undertaken to work out the serum transferrin receptor’s ability to differentiate iron-deficiency anemia from the anemia of chronic inflammation and to spot iron deficiency in patients with disease . The mean transferrin receptor level in 17 normal controls was 5.36 ± 0.82 mg/ L compared with 13.91 ± 4.63 mg/L in 17 patients with iron-deficiency anemia (p < 0.001). The mean serum receptor level was normal altogether 20 patients with acute infection, including five with acute hepatitis, and was also normal in 8 of 10 anemic patients with chronic disease . Receptor levels were within the normal home in about 4 of 41 patients with anemia of chronic disease. We conclude that unlike serum ferritin levels, which are disproportionately elevated in reference to iron stores in patients with inflammation or disease , the serum transferrin receptor level isn’t suffering from these disorders and is therefore a reliable laboratory index of iron deficiency anemia. 
Hemoglobin and hepcidin have good validity and utility for diagnosing iron deficiency anemia among pregnant women
Background/Objectives: Screening and diagnosis of iron deficiency anemia (IDA) is cumbersome because it may require testing for hemoglobin, ferritin, and an inflammatory biomarker. The aim of this study was to match the diagnostic capacity of hematologic biomarkers to detect IDA among pregnant women in Tanzania.
Subjects/Methods: We pooled data from an iron supplementation trial of 1500 iron-replete pregnant woman and a prospective cohort of 600 iron-deficient pregnant women. Receiver operating characteristic curves (ROC) for hematologic biomarkers were wont to assess the sensitivity, specificity, and area under the curve (AUC) for iron deficiency (ID) and iron deficiency anemia (IDA), crude, or corrected for inflammation. Regression models assessed the connection of baseline biomarker categories (gestational age 
Oral versus Parenteral Iron Supplements: Which is better in Postpartum Iron Deficiency Anemia?
Aims: To assess the security and effectiveness of iron sucrose complex given intravenously versus ferrous sulphate taken orally within the treatment of iron deficiency anemia within the postpartum period.
Study Design: Randomized clinical test .
Place and Duration of Study: Sahiwal Medical College, Sahiwal (Pakistan) from August to November, 2017.
Methodology: We included 386 patients with Iron Deficiency Anemia in postpartum period consistent with our criteria and distributed them among two groups. Group-A patients received intravenous Iron Sucrose complex while Group-B patients were treated with oral iron sulfate. Hemoglobin level, hematocrit, mean corpuscular volume and serum ferritin were used as indicators of anemia and results obtained for reversal of anemia and frequency of adverse effects were later analyzed. 
 Bainton, D.F. and Finch, C.A., 1964. The diagnosis of iron deficiency anemia. The American journal of medicine, 37(1), (Web Link)
 Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A. and Vaulont, S., 2002. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proceedings of the National Academy of Sciences, 99(7), (Web Link)
 Ferguson, B.J., Skikne, B.S., Simpson, K.M., Baynes, R.D. and Cook, J.D., 1992. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. The Journal of laboratory and clinical medicine, 119(4), (Web Link)
 Hemoglobin and hepcidin have good validity and utility for diagnosing iron deficiency anemia among pregnant women
Ajibola I. Abioye, Said Aboud, Zulfiqarali Premji, Analee J. Etheredge, Nilupa S. Gunaratna, Christopher R. Sudfeld, Ramadhani A. Noor, Ellen Hertzmark, Donna Spiegelman, Christopher Duggan & Wafaie Fawzi
European Journal of Clinical Nutrition (2019) (Web Link)
 Nawaz, A., Aslam, A. and ., Q.-U.-A. (2018) “Oral versus Parenteral Iron Supplements: Which is better in Postpartum Iron Deficiency Anemia?”, Asian Journal of Research in Medical and Pharmaceutical Sciences, 3(2), (Web Link)