Selection of patients with gastric adenocarcinoma for laparoscopic staging
To refine selection criteria for laparoscopic staging of gastric adenocarcinoma, preoperatively available clinical and radiologic factors that may predict the risk of M1 disease were investigated.
During 1993–2002, laparoscopy was performed if patients had minimal symptoms and there was no definite M1 disease at computed tomography (CT) scanning. High-quality, spiral, CT scans were reviewed in detail for 65 recent patients.
Laparoscopy was conducted for 657 patients and M1 was detected in 31%. M1 was significantly more prevalent with tumor location at the gastroesophageal junction (GEJ; M1 in 42%) or whole stomach (66%), poor differentiation (36%) or age ≤70 years (34%). On spiral CT scan, lymphadenopathy ≥1 cm (49%) or T3/T4 tumors (63%) were associated with significantly higher prevalence of M1. On multivariate analyses, only tumor location (GEJ or whole stomach) and lymphadenopathy were independently significant and M1 was not detected in any patient with neither risk factor.
With spiral CT staging, laparoscopy may be avoided if the primary tumor is not at the GEJ or whole stomach and there is no lymphadenopathy. 
Adenocarcinoma in situ of the cervix
Adenocarcinoma in situ (ACIS) of the cervix is rare and is frequently overlooked. To characterize this disease more fully, 21 cases were studied. All except two patients presented with abnormal smears. The distribution of ACIS was focal in two cases, multicentric in three, and diffuse and continuous in 15 (in one case it was unknown). The depth of crypt involvement varied from 0.5 to 4 mm and the volume was estimated to range from 0.25 to 1,500 mm3. ACIS should and can be distinguished from early (“microinvasive”) adenocarcinoma in most cases by its limitation to the glandular field, by the constant admixture of neoplastic and normal glands, and by the lack of stromal response. Invasive adenocarcinoma cannot be excluded by target biopsy, the diagnosis of ACIS requiring conization. If the surgical margins are disease free, conization alone may be adequate therapy. 
Inflammatory events in endometrial adenocarcinoma
Endometrial adenocarcinoma is the most common gynaecological malignancy in western countries. Many of the established risk factors for developing endometrial cancer are associated with excess exposure to oestrogen unopposed by progesterone. These include nulliparity, late onset of the menopause, post-menopausal hormone replacement therapy and obesity. However, a number of risk factors also promote inflammation, another feature proposed to influence cancer development. The human cycling endometrium undergoes regular and cyclical episodes of inflammation. Moreover, hormonal and genetic changes that occur early in the development of endometrial adenocarcinoma can exacerbate the local inflammatory environment. Via alterations in the expression of local mediators and immune cell function, these may contribute to the development of endometrial cancer. This review discusses the contribution of inflammation to the initiation and progression of endometrial adenocarcinoma. Manipulation of inflammatory pathways may therefore represent a therapeutic target in endometrial adenocarcinoma. 
A Rare Case of Metastatic Adenocarcinoma of Stomach Metastasizing into Metachronous Gist of Small Intestine
Gastrointestinal stromal tumours (GIST) are rare mesenchymal neoplasms in the gastrointestinal tract. The metachronous existence of GIST and gastric adenocarcinoma, though are tumours of distinct histotype, and very rare, have been reported in medical case reports in recent years.
We report a case of a 74 year old man who initially presented with moderately differentiated adenocarcinoma of the stomach, underwent Billroth 2 gastrectomy followed by chemotherapy. Subsequently, after 15 months he developed a GIST of small bowel with metastasis from adenocarcinoma of stomach.
Taking into consideration the fact that metachronous occurrence of GIST of the gastrointestinal tract and adenocarcinoma of stomach is rare and further metastasis of one tumour into the other makes this case a rare one as per available literature. 
Could Monocytes Colonized by Circulating Epithelial Cells of the Prostate Gland be a Source of Metastasis of the Adenocarcinoma? A Hypothesis Based on a Previous Study
Background: Recently we reported the successful in vitro cultivation of prostatic epithelial and stromal cells from patients with benign prostatic hyperplasia and adenocarcinoma of the prostate by liquid biopsy. In that study we noticed monocytes that were colonized by prostatic epithelial cells; this was confirmed using a monoclonal antibody to prostate epithelial cells. We also detected a deleterious effect exerted on the monocyte cytoplasm by a process yet to be determined.
Aim: To develop a hypothesis that will explain the significance of monocytes colonized by prostatic epithelial cells in the pathogenesis of prostate adenocarcinoma.
Study Design: Retrospective analysis of images in the previous study.
Place and Duration: Kilimanjaro Christian Medical University College, Tumaini University, Moshi, Tanzania. One month.
Results: We found that all monocytes viewed, without exception, contained intra-cytoplasmic prostatic epithelial cells and most of them presented with apparent cytopathology. The cytopathology presented as strand formation and shrinkage of monocytes. Often the loss of integrity of monocyte cytoplasm could be arbitrarily graded as little to complete loss of cytoplasm.
Conclusion: We hypothesize that epithelial cells invade monocytes and colonize the cytoplasm. Monocytes colonized by epithelial cells then participate in the metastatic process of the prostate adenocarcinoma to different parts of the body. We report for the first time, a monocyte colonized by an epithelial cell of the prostate gland. This could also be an unrecognized phenomenon with other types of cancers. 
 Sarela, A.I., Lefkowitz, R., Brennan, M.F. and Karpeh, M.S., 2006. Selection of patients with gastric adenocarcinoma for laparoscopic staging. The American journal of surgery, 191(1), pp.134-138.
 Ostör, A.G., Pagano, R., Davoren, R.A., Fortune, D.W., Chanen, W. and Rome, R., 1984. Adenocarcinoma in situ of the cervix. International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists, 3(2), pp.179-190.
 Wallace, A.E., Gibson, D.A., Saunders, P.T. and Jabbour, H.N., 2010. Inflammatory events in endometrial adenocarcinoma. The Journal of endocrinology, 206(2), pp.141-157.
 Rodrigues, J., Kumar, S., Vaz, O. P. and Salelkar, R. (2015) “A Rare Case of Metastatic Adenocarcinoma of Stomach Metastasizing into Metachronous Gist of Small Intestine”, Journal of Advances in Medicine and Medical Research, 13(1), pp. 1-4. doi: 10.9734/BJMMR/2016/22002.
 Nyindo, M., Hamid Lukambagire, A.- and Mimano, L. (2016) “Could Monocytes Colonized by Circulating Epithelial Cells of the Prostate Gland be a Source of Metastasis of the Adenocarcinoma? A Hypothesis Based on a Previous Study”, Journal of Cancer and Tumor International, 4(2), pp. 1-5. doi: 10.9734/JCTI/2016/28227.