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News Update on Nigella Sativa Research: Oct – 2019

October 24, 2019October 24, 2019 by Editor NetKumar

Antioxidant activity of Nigella sativa essential oil

The oil of black cumin seeds, nigella L., was tested for a potential inhibitor activity. A fast analysis for antioxidants, victimization 2 tending screening strategies, showed that thymoquinone and therefore the parts carvacrol, t‐anethole and 4‐terpineol incontestible respectable radical scavenging property. These four constituents and therefore the oil possessed variable inhibitor activity once tested within the diphenylpicrylhydracyl assay for non‐specific atom or negatron donating activity. They were conjointly effective •OH radical scavenging agents within the assay for non‐enzymatic supermolecule peroxidation in liposomes and therefore the saccharide degradation assay. [1]

Fixed Oil of Nigella sativa and Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipid Peroxidation

Samples of the expressed oil from totally different sources of nutmeg flower seeds were examined by thin-layer and gas activity for content of fastened oils and thymoquinone, and these substances were tested as potential inhibitors of eicosanoid generation and membrane supermolecule peroxidation. The crude oil and pure thymoquinone each pent-up the cyclo-oxygenase and 5-lipoxygenase pathways of arachidonate metabolism in rat serosa leukocytes stirred with atomic number 20 ionophore A23187, as shown by dose-dependent inhibition of thromboxane B2 and leukotriene B4, severally. Thymoquinone was terribly potent, with approximate IC50 values against 5-lipoxygenase and cyclo-oxygenase of [2]

Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat

Nigella sativa (ranunculaceae) is employed in Arab folks medication as a diuretic drug and hypotensive plant. we have a tendency to report here the diuretic drug and hypotensive effects of chloride extract of Roman coriander seeds within the ad libitum hypertensive rat (SHR). AN oral dose of Roman coriander extract (0.6 ml/kg/day) and water pill (5 mg/kg/day) hyperbolic considerably the symptom by sixteen and thirty per cent severally when fifteen days of treatment; urinary excretion of Cl-, Na+, K+ and carbamide is additionally hyperbolic. at the same time, the mean blood pressure shriveled severally by twenty two and eighteen per cent within the Roman coriander treated rat and calcium-channel blocker treated rat (0.5 mg/kg/day). finally, the diuretic drug activity determined within the SHR rat treated with Roman coriander seeds is also part accountable for its diuretic drug action; it appears that different pathways may additionally  be concerned in their vessel effects. [3]

Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm

Bacterial spoilage of food product is regulated by density dependent communication system known as gathering sensing (QS). QS management biofilm formation in various food pathogens and Biofilms fashioned on food surfaces act as carriers of microorganism contamination resulting in spoilage of food and health hazards. Agents inhibiting or intrusive with microorganism QS and biofilm are gaining importance as a unique category of next-generation food preservatives/packaging material. within the gift study, metallic element nanostructures were synthesised exploitation nutmeg flower seed extract (NS-ZnNPs). Synthesized nanostructures were characterised hexangular wurtzite structure of size ~24 nm by UV-visible, XRD, FTIR and TEM. NS-ZnNPs incontestible broad-spectrum QS inhibition in C. violaceum and P. aeruginosa biosensor strains. Synthesized nanostructures pent-up QS regulated functions of C. [4]

Therapeutic Effect of Nigella sativa on Alcohol-induced Liver Disease in Rats

Background: Alcohol-induced unwellness} disease is that the earliest liver disorder related to excessive consumption of alcohol. numerous treatment regimens are planned for the treatment of alcohol-induced liver disorders as well as the utilization of healthful plants like Nigella sativa (NS), a miracle plant with a large spectrum of activities.

Objective: The aim of the current study was to analyze the therapeutic property of NS total oil (TO) and neutral macromolecule fraction (NLF) on alcohol-induced liver injury in male anomaly rats. Methodology: The TO was 1st extracted from NS seed, so fractionated employing a tube to get the NLF. These 2 extracts were used one by one as treatment regime for alcohol-induced liver toxicity in rats. Some liquid body substance organic chemistry markers of viscus operate as well as aspartate transaminase (AST), aminoalkanoic acid transaminase (ALT), and base-forming enzyme (ALP) and histopathological options of the liver section were assessed, and results were compared to those within the management cluster. [5]

Reference

[1] Burits, M. and Bucar, F., 2000. Antioxidant activity of Nigella sativa essential oil. Phytotherapy research, 14(5), (Web Link)

[2] Houghton, P.J., Zarka, R., de las Heras, B. and Hoult, J.R.S., 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta medica, 61(01), (Web Link)

[3] Zaoui, A., Cherrah, Y., Lacaille-Dubois, M.A., Settaf, A., Amarouch, H. and Hassar, M., 2000. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie, 55(3), (Web Link)

[4] Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm
Nasser A. Al-Shabib, Fohad Mabood Husain, Faheem Ahmed, Rais Ahmad Khan, Iqbal Ahmad, Edreese Alsharaeh, Mohd Shahnawaz Khan, Afzal Hussain, Md Tabish Rehman, Mohammad Yusuf, Iftekhar Hassan, Javed Masood Khan, Ghulam Md Ashraf, Ali Alsalme, Mohamed F. Al-Ajmi, Vadim V. Tarasov & Gjumrakch Aliev
Scientific Reports volume6, Article number: 36761 (2016) (Web Link)

[5] Mosbah, A., Zettal, H., Khither, H., Mosbah, C., Kacem Chaouche, N. and Benboubetra, M. (2017) “Therapeutic Effect of Nigella sativa on Alcohol-induced Liver Disease in Rats”, European Journal of Medicinal Plants, 20(1), (Web Link)

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