Vindolanda tablets
The Latin writing tablets from Vindolanda, a Roman auxiliary fort a few mile south of Hadrian’s Wall, were discovered by the anthropologist R. E. Birley in excavations of components of the pre‐Hadrianic timber forts throughout the amount 1974–2004. [1]
Abuse resistant tablets
This invention relates to associate abuse resistant pill containing 2 or a lot of layers having one or more medicine and one or more gelling agents and its preparation. The drug(s) and gelling agent(s) are in separate layers of the pill. The multilayer pill is especially appropriate for the administration of medication vulnerable to abuse by unauthorized duct administration like analgesics, hypnotics, and anxiolytics. [2]
FDA Drug Approval Summary: Gefitinib (ZD1839) (Iressa®) Tablets
On May 5, 2003, gefitinib (Iressa®, ZD1839) 250-mg tablets received accelerated approval by the U.S. Food and Drug Administration as monotherapy treatment for patients with domestically advanced or pathologic process non-small cell carcinoma (NSCLC) when failure of each platinum-based and docetaxel chemotherapies. info provided during this outline includes efficaciousness and safety results of relevant clinical trials. Effectiveness was incontestible in a very randomised, double-blind, phase II, multicenter trial examination 2 oral doses of gefitinib (250 mg/day versus five hundred mg/day). 2 hundred sixteen patients were listed. The 142 patients UN agency were refractory to or impatient a noble metal and docetaxel comprised the evaluable population for the efficaciousness analysis. A partial tumour response occurred in 14 July (9 of 66) of patients receiving gefitinib 250 mg/day and in V-day (6 of 76) of patients receiving gefitinib five hundred mg/day. the objective response rate for each doses combined was ten.6% (15 of 142 patients) (95% confidence interval vi.0%–16.8%). Responses were additional frequent in females and in nonsmokers. The median length of response was seven.0 months (range four.6–18.6+ months). [3]
Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
The aim of this study was to explore the feasibleness of consolidated deposition modeling (FDM) 3D printing to arrange intragastric floating sustained unharness (FSR) tablets. Domperidone (DOM), Associate in Nursing insoluble weak base, was chosen as a model drug to research the potential of FSR in increasing its oral bioavailability and reducing its administration frequency. DOM was with success loaded into hydroxypropyl polyose (HPC) filaments exploitation hot soften extrusion (HME). The filaments were then written into hollow structured tablets through ever-changing the shell numbers and therefore the infill percentages. Physical characterization results indicated that the bulk of DOM step by step changed into the amorphous kind throughout the fabrication method. The optimized formulation (contain 100% DOM, with two shells and third infill) exhibited the sustained unharness characteristic and was ready to float for regarding 10 h in vitro. photography pictures showed that the BaSO4-labeled tablets were preserved within the abdomen of rabbits for over 8 h. what is more, pharmacokinetic studies showed the relative bioavailability of the FSR tablets compared with reference business tablets was 222.49 ± 62.85%. All the results showed that FDM primarily based 3D printing may well be a promising thanks to fabricate hollow tablets for the aim of intragastric floating drug delivery. [4]
Kinetic and Energetic Correlations in the Reaction of Vitamin-C Tablets
The oxidisation time supported the fitting of experimental knowledge was taken out. Drawing of the Absorbance (λmax=265 nm) vs. oxidisation time (sec) of Vitacid C by K2 CrO4 were studied. Energy consumed throughout aerophilous degradation of vitamin-C(Vit-C) Tablets in liquid metallic element salt (K2CrO4) medium was studied spectrophometrically at 25°C. The reduction of the absorbance at~ 265 nm with increasing time was scanned. an honest one-dimensionality (R-square ≥ zero.99). The slope (EC/ppm) vs chemical agent (Vit-C/ppm) at constant oxidizer is concerning one.218, while, the slope of EU vs. oxidizer (K2CrO4 /ppm) is concerning three.653. Calculations counsel that the EU throughout reduction of atomic number 24 (VI) to atomic number 24 (III) is concerning thrice of magnitude quicker than the oxidisation of the Vit – C sample. [5]
Reference
[1] Bowman, A.K., 2013. Vindolanda tablets. The Encyclopedia of Ancient History. (Web Link)
[2] Bastin, R.J. and Lithgow, B.H., Aventis Pharma Ltd, 2001. Abuse resistant tablets. U.S. Patent 6,309,668. (Web Link)
[3] Cohen, M.H., Williams, G.A., Sridhara, R., Chen, G. and Pazdur, R., 2003. FDA drug approval summary: gefitinib (ZD1839)(Iressa®) tablets. The oncologist, 8(4), pp.303-306. (Web Link)
[4] Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone
Xuyu Chai, Hongyu Chai, Xiaoyu Wang, Jingjing Yang, Jin Li, Yan Zhao, Weimin Cai, Tao Tao & Xiaoqiang Xiang
Scientific Reportsvolume 7, Article number: 2829 (2017) (Web Link)
[5] Ahmed, S. M. and Shahata, M. M. (2018) “Kinetic and Energetic Correlations in the Reaction of Vitamin-C Tablets”, Chemical Science International Journal, 25(1), pp. 1-7. doi: 10.9734/CSJI/2018/45058. (Web Link)