The steady decrease in the therapeutic effectiveness of available pharmaceutical products due to the spread of antimicrobial resistance underscores the need to create new groups of antimicrobial agents to treat infectious diseases. This urgency has inspired researchers to discover a relatively new and sustainable tool called host-defense peptides, also called antimicrobial peptides (AMPs), to fight against pathogenic microorganisms. Over 3000 natural AMPs from a variety of species, including archaea, protists, fungi , bacteria, plants and animals, have been discovered to date. AMPs can exert antimicrobial activity by directly destroying microbial pathogens or indirectly modulating the host immune systems. Furthermore, AMPs have other major biological functions, such as anti-biofilm, anti-cancer and wound healing activities, immunomodulatory and regenerative effects, or even gut microbiota control. In this chapter, we address the characteristics, biological function, Such as anti-biofilm, anticancer and wound healing operations, immunomodulatory and regenerative properties, or even gut microbiota control. In this chapter, along with various models illustrating the killing mechanism of AMPs, we discuss the properties, biological function, classification, and mode of action of AMPs. In the end, we will also explore the possibilities and opportunities. Challenges in constructing these AMPs as creative therapies.
Author (s) Details
Dr. Tahsina Shireen
Department of Zoology, Gauhati University, Guwahati 781014, Assam, India.
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