Because aspirin, also known as acetyl salicylic acid or 2-acetoxybenzoic acid, contains a carboxylic acid functional group, it is easier to measure using a strong alkali such as NaOH. Aspirin overdoses can have devastating consequences, including death and considerable morbidity. In most analgesic medication formulations in tablet form, aspirin is bound or compounded with other excipients or substituents that are acidic in nature and include acidic groups, making sodium hydroxide an ineffective reagent for measuring aspirin in multicomponent aspirin tablet formulations. Six distinct pills containing aspirin as the active ingredient were taken from a reputed medicine manufacturing firm. While UV-VIS spectroscopy via multivariate calibration gave values at the lower limit or outside the lower limits of the US & BP pharmacopoeia with respect to label claims, while HPLC gave very good resolution and precise results within the pharmacopoeia limits, methods using sodium hydroxide as the main reagent in quantification involve a lot of stoichiometric mathematical manipulations as in the case of titrimetric method.

Author(S) Details

Ochieng Anthony
Department of Science, Sumait University, Tanzania.

Hemed S. Moh’d
Department of Science, Sumait University, Tanzania.

Mataka A. Mataka
Department of Science, Sumait University, Tanzania.

Abdul Juma
Department of Science, State University of Zanzibar, Tanzania.

Ochieng J. Odalo
Department of Pure and Applied Sciences, Technical University of Mombasa, Kenya.

Okoli C. Peter
Department of Chemistry-Analytical Unit, Vaal University of Technology, South Africa.

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