In the present study, effect of Heterometrus fastigiousus Couzijn (Family: Scorpionidae) venom on
alkaline phosphatase (ALP), acid phosphatase (ACP), lactic dehydrogenase (LDH) and glutamatepyruvate
transaminase (GPT) enzyme activity, and red blood cells (RBCs) count, white blood cells
(WBCs) count, blood hemoglobin, mean corpuscular hemoglobin (MCH), packed cell volume (PCV)
and plasma hemoglobin in experimentally envenomed albino mice was studied. Venom was obtained
by electrical stimulation and its toxicity was determined in albino mice by subcutaneous
envenomation. The LD50 was 18.6 mg kg-1 body weight of mice. H. fastigiousus venom caused
significant increase in ALP, ACP, LDH and GPT activity in liver tissue of albino mice. This venom
reduced RBC count and increased WBC count, blood hemoglobin, MCH, PCV and plasma
hemoglobin. Findings of this study will help to understand the mechanism of Asian black scorpion,
- fastigiousus venom toxicity.
Author (s) Details
Mukesh Kumar Chaubey
Department of Zoology, National Post Graduate College, Barhalganj, Gorakhpur – 273402, Uttar Pradesh, India.
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