How does Parkinson’s disease develop? The study raises doubts on the theory of Parkinson’s disease
Parkinson’s disease was initially delineated by a British doctor quite two hundred years’ agone. the precise causes of this neurodegenerative illness square measure still unknown. in a very study recently revealed in eLife, a team of researchers light-emitting diode by the professor. Henning Stahlberg from the Biozentrum of the University of Basel has currently questioned the previous understanding of this illness. 
Cerebrospinal fluid concentrations of inflammatory markers in Parkinson’s disease and atypical parkinsonian disorders
Inflammation has been involved in the pathological process of Parkinson’s unwellness (PD). we tend to here investigate levels of inflammatory biomarkers in a bodily fluid (CSF) in Pd and atypical parkinsonian disorders (APD) compared with neurologically healthy controls. we tend to enclosed 131 patients with Pd and twenty-seven Pd with insanity (PDD), twenty-four with multiple system atrophy (MSA), fourteen with progressive supranuclear palsy (PSP) and fifty controls, all a part of the Swedish BioFINDER study. CSF was analyzed for C-reactive protein, SAA, IL-6, IL-8, YKL-40 and MCP-1 (CCL2) as well as α-synuclein (α-syn), tau, letter phosphorylated at Thr181 (P-tau), Aβ42 and NFL. during this searching study, we tend to found higher levels of the inflammatory biomarker SAA in PdD and MSA compared with controls and Pd and better levels of C-reactive protein in PDD and MSA compared with PD. 
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease
Increasing the operate of residual dopaminergic neurons within the Black of atomic number 46 patients is a vital space of analysis because it might eventually compensate the loss. though aminoalkanoic acid hydroxylase (TH) is that the rate-limiting catalyst within the Dopastat (DA) synthesis pathway, there are not any effective drugs/molecules to upregulate TH and increase the assembly of the prosecutor in nigral dopaminergic neurons. This study underlines the importance of painkiller in stimulating the expression of TH and increasing the amount of prosecutor in dopaminergic neurons. At low doses, painkiller accrued the expression of TH and therefore the production of the prosecutor in mouse MN9D dopaminergic vegetative cell cells. consequently, oral administration of aspirin increased the expression of TH in the nigra and upregulated the level of DA in the striatum of normal C57/BL6 mice and aged A53T α-syn transgenic mice. 
Rare genetic variation in mitochondrial pathways influences the risk for Parkinson’s disease
Background: Mitochondrial pathology plays a key role in atomic number 46, however, the underlying molecular mechanisms stay unresolved. we tend to hypothesize that the disruption of mitochondrial perform in atomic number 46 is ready by rare, protein‐altering variation in nuclear genes controlling mitochondrial structure and function.
Objective: the target of this study was to assess whether or not genetic variation in genes related to mitochondrial performs influences the danger of upset atomic number 46. 
Analysis of Motor Complications in Parkinson’s Disease Phenotypes
Patients with palladium were registered within the analysis study and underwent examination on movement disorder and drug-induced motor complication by UPDRS III and IV. Hoehn and Yahr scale was accustomed describe the intermediate course of unwellness. All antiparkinsonian medication was calculated on theoretical equivalence to Bendopa. 208 patients were divided into 3 subgroups: tremor-dominant fifty,4%, akinetic-rigid forty-one,9% and blend kind seven,7%. All patients were treated with Bendopa, and regarding 3 quarters were together with a monoamine neurotransmitter agonist. Regarding unwellness length and developing of spouting off, there was a vital distinction in step with clinical makeup. 
 How does Parkinson’s disease develop? The study raises doubts on the theory of Parkinson’s disease
Date: July 9, 2018, Source: University of Basel (web link)
 Cerebrospinal fluid concentrations of inflammatory markers in Parkinson’s disease and atypical parkinsonian disorders
Hall S, Janelidze S, Surova Y, Widner H, Zetterberg H, Hansson O. Cerebrospinal fluid concentrations of inflammatory markers in Parkinson’s disease and atypical parkinsonian disorders. Scientific Reports. 2018 Sep 5;8(1):13276. (web link)
 Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease
Rangasamy SB, Dasarathi S, Pahan P, Jana M, Pahan K. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease. Journal of Neuroimmune Pharmacology. 2018:1-5. (web link)
 Rare genetic variation in mitochondrial pathways influences the risk for Parkinson’s disease
Gaare JJ, Nido GS, Sztromwasser P, Knappskog PM, Dahl O, Lund‐Johansen M, Maple‐Grødem J, Alves G, Tysnes OB, Johansson S, Haugarvoll K. Rare genetic variation in mitochondrial pathways influence the risk for Parkinson’s disease. Movement Disorders. 2018. (web link)
 Analysis of Motor Complications in Parkinson’s Disease Phenotypes
Nargiza Mansurova1,2* and Q. Khaydarova Dildora3
1Department of Neurology and Psychiatry, Bukhara State Medical Institute, Uzbekistan.
2Department of Neurology, Tashkent medical academy, Uzbekistan.
3Bukhara state Medical Institute, Uzbekistan. (web link)