Neeradimuthu Vallathi Mezhugu, a Traditional Siddha Herbo-not organic formulation is indicated for individual type of Vali diseases namely Thandaga Vatham. To ensure the security and influence of this medication, pre-dispassionate study was conducted. This Internal Medicine search out be given to patients in a dosage of 1 gm. twice a day for a ending of 48 days. According to shastric literature, the trial medications were conceived. Analgesic and anti-angering studies were conducted as part of this drug’s preclinical safety (acute spoken and repeated spoken toxicity) and efficacy trials. Blood counts and Hb% acted not significantly alter all the while the 15-day spoken toxicity study with the medication. In severe experimental inflammatory environments in rats, the test medication demonstrated notable anesthetic and anti-instigative action. The test drug demonstrated defeater in competition anti-inflammatory venture at the end of the one of four equal parts hour following carrageenan challenge; the mechanism of antagonistic-inflammatory activity of the test drug grant permission be attributed to allure inhibitory activity on cyclooxygenase (COX) enzymes. Moreover, phytochemical and antioxidant studies revealed allure efficacy in treating Vatha afflictions, particularly Thandaga Vatham.

Author(s) Details:

K. S. Maanickha Chelvi,
Siddha Medicinal Plants Garden, (Under C.C.R.S, Ministry of Ayush, Govt.of India), Mettur, Tamilnadu, India.

V. Mahalakshmi,
Department Siddhar Yoga Maruthuvam, National Institute of Siddha, Chennai, India.

N. J. Muthukumar,
Varma Maruthuvam, National Institute of Siddha, Chennai, India.

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Keywords: Siddha system, Thandaga Vatham, Neeradimuthu Vallathi Mezhugu, preclinical, toxicity, anti-inflammatory