Cancer refers to the uncommon growth of containers with the invasive type, mainly grown due to breakdown in immune defence mechanism. The rudimentary development, tumour tumor and metastasis of malignancy are governed by angiogenesis, that revenue under a suitable condition of the triggering of angiogenic switch accompanying a net balance between the supporting-angiogenic and anti-angiogenic determinants. The current study shows that the anticancer activity of chitosan is associated with the basic pathways of deoxyribonucleic acid (DNA) dysfunction and apoptosis, inhibition of the substance causing chemicals to split into simpler substances ribonucleotide reductase (RR), induction of complete and sudden withdrawal from an addictive substance enzymes, immunopotentiation, anti-metastasis by way of the interference in basic invasion and action, and the natural antioxidant sketch increment via the scavenging of tumor-causing free radicals. The study of the basic pathways of anticancer activity of chitosan is important towards the synthetic customization and tailoring of chitosan biomaterial as a powerful anticancer drug candidate. The aims of the study lie on verdict the putative natural routes of cancer pathophysiology and proliferation, and the mechanistic approaches of anticancer endeavor of chitosan that are expected expected important engaged of research, specifically on chitosan based anticancer drug formulations incident strategy.
Author(s) Details:
J. Topinka,
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine AS CR, Videnska 8 1083, 142 20 Prague 4, Czech Republic.
P. Rossner,
Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine AS CR, 10 Videnska 1083, 142 20 Prague 4, Czech Republic.
A. Rossnerova,
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine AS CR, Videnska 8 1083, 142 20 Prague 4, Czech Republic.
R. J. Sram,
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine AS CR, Videnska 8 1083, 142 20 Prague 4, Czech Republic.
Please see the link here: https://stm.bookpi.org/CODHR-V9/article/view/9179
Keywords: Air pollution, alzheimer’s disease, dementia, epigenetic adaptation, molecular epidemiology, particulate matter