Cancer refers to the strange progress of containers accompanying the invasive type, primarily grown on account of loss in invulnerable defence mechanism. The rudimentary growth, tumour development and often major of malignancy are ruled by angiogenesis, that profit under a suitable condition of the prompting of angiogenic switch accompanying a net balance middle from two points the supporting-angiogenic and antagonistic-angiogenic determinants. The current study shows that the anticancer endeavor of chitosan is associated with the natural pathways of deoxyribonucleic acid (DNA) dysfunction and apoptosis, hindrance of the substance causing chemicals to split into simpler substances ribonucleotide reductase (RR), inference of complete and sudden withdrawal from an addictive substance enzymes, immunopotentiation, antagonistic-change via the impedance in basic encroachment and action, and the unaffected antioxidant sketch increment by way of the scavenging of tumor-leading to free radicals. The study of the natural pathways of anticancer venture of chitosan is critical towards the artificial customization and tailoring of chitosan biomaterial as a powerful anticancer drug aspirant. The aims of the study thrust judgment the presumptive basic routes of cancer pathophysiology and conception, and the mechanistic approaches of anticancer endeavor of chitosan that be necessary expected main engaged of research, specifically on chitosan located anticancer drug formulations incident approach.

Author(s) Details:

Hari Sharan Adhikari,
Department of Applied Sciences, Institute of Engineering, Pashchimanchal Campus, Tribhuvan University, Pokhara, Nepal.

Paras Nath Yadav,
Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal.

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Keywords: Anticancer activity, anticancer pathways, cancer, chitosan, nano chitosan