QSAR Investigation on 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamides as EGFR Kinase Inhibitors

In order to establish a quantitative relationship between epidermal growth factor receptor (EGFR) kinase inhibitory activity and physicochemical / structural properties, a quantitative structure activity relationship (QSAR) study was performed on a series of 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamides. Using multiple linear regression (MLR)

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Study on Synthesis and Appraisal of Some 2,5-Disubstituted-1,3,4-Thiadiazoles as Diuretic Agents

Acetazolamide and Methazolamide are diuretic 1,3,4-thiadiazole compounds that are well-known. As a result, certain novel 2,5-disubstituted-1,3,4-thiadiazoles were synthesised and diuretic efficacy was tested. The diuretic action of a handful of the compounds, including IVa1, IVb2, and IVc2, was comparable to

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Determining the Effect of 1, 3, 5-trimethyl-2, 6-diphenyl Piperidin-4-one Oxime on the Electrochemical Behaviour of Mild Steel in HCl Medium

The corrosion inhibitory capacity of a synthetic heterocyclic molecule, namely 1, 3, 5-trimethyl-2, 6-diphenyl piperidin-4-one oxime, was evaluated using weight loss experiments, electrochemical methods, and SEM examinations in 1M hydrochloric acid (HCl) media against mild steel (MS) (TPO). The weight

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Study on Synthesis and Characterization of New 8- Trifluloromethyl Quinazolin-2,4-(3H)-Dione Nucleosides

The synthesis of 8-trifluloromethyl quinazolin-2,4-(1H,3H)-dione 2, which was ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl—D-ribofuranose 4 via the silylation method, yielded mixture and -anomeric benzoylated nucleoside derivatives 5 and 6, respectively. As part of our ongoing interest in the synthesis of new

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Isolation, Characterizations of Bioactive Principles from Melia dubia Leaf and Its In-silico and In-vitro Urolithiatic Activity

Many medicinal plants contain a wide range of bioactive compounds at various levels. The primary goal of this research is to identify and separate antioxidants from different extracts of Melia dubia leaves. Soxhlet extraction was used with solvents such as

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5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA Interactions

One of the most important aspects of the manufacture of medicinal drugs is the synthesis of novel thiadiazoles. Current medicinal chemistry research has focused on the properties of new compounds with possible novel structural features and biological applications. In this

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Recent Study on Synthesis of Novel Series of Quinolino [3,2-f][1,2,4] triazolo [3,4-b][1,3,4] Thiadiazepines Derivatives Incorporated with 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl) Moiety as Potent Antimicrobial Agent

A Quinolino novel series[3,2-f] [1,2,4] The [3,4-b] Triazolo [1,3,4] The Thiadiazepine (7a-i) derivatives incorporated with 3-(5--i) (benzofuran-2-yl) -1-phenyl-1H-3-yl pyrazol) Moiety was synthesised by a 5-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)) one-point cyclo-condensation reaction. -4-amino-4H-1,2,4-triazole-3-thiol (4) in the presence of K2CO3 in DMF with 2-chloro-quinoline-3-carbaldehyde derivatives

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Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products

The present study seeks to investigate the synthesis and structural characteristics of derivatives of Indanone, Tetralone and Naphthone. Via Claisen condensations, arylhydrazine condensations, BakerVenkataraman rearrangements, Claisen-Schmidt reactions, selective fluorinations and trifluoroacetylations in yields ranging from 22-92 percent, indanone, tetralone and

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