Isatin Derivatives as Human Intestinal Carboxylesterase Inhibitors: An Approach towards 3D-QSAR, Pharmacophore and Molecular Docking

Carboxylesterases (CEs) metabolise a variety of medications, and inhibiting them can increase the bioactivity or reduce the toxicity of substances activated by these enzymes. Isatin derivatives that were previously described as carboxylesterase inhibitors were chosen to develop a quantitative structure-activity

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