Study on Synthesis and Appraisal of Some 2,5-Disubstituted-1,3,4-Thiadiazoles as Diuretic Agents

Acetazolamide and Methazolamide are diuretic 1,3,4-thiadiazole compounds that are well-known. As a result, certain novel 2,5-disubstituted-1,3,4-thiadiazoles were synthesised and diuretic efficacy was tested. The diuretic action of a handful of the compounds, including IVa1, IVb2, and IVc2, was comparable to

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