A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report
An efficient and novel strategy has been developed using potassium carbonate as catalyst for synthesis of 4-amino-2-methyl-6-(methylthio)pyrimidine-5-carbonitrile (3) by condensing acetamidine hydrochloride (1) with bis(methylthio)methylene malononitrile (2) in DMF. Compound (3) is susceptible to nucleophilic substitution reaction due to presence
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