Design of Bitterless Atenolol Prodrugs for the Use in Aqueous Formulations for Pediatrics and Geriatrics

A number of atenolol prodrugs were created using DFT, MP2, and hybrid GGA: MPW1k calculations for an acid-catalyzed hydrolysis of nine Kirby's N-alkylmaleamic acids. A linear association between the estimated and experimental rate values for the nine Kirby's N-alkylmaleamic acids

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