Investigating the Sequence Variation in E2-Binding Domain of HPV16 and Biological Function Evaluation in Tunisian Cervical Cancers

Infection with hr-HPV (high-risk human papillomaviruses) is a necessary but insufficient cause of invasive cervical cancer, with additional virus-host interactions required for cancer to develop. The transcriptional activity of the LCR is affected differently by HPV16 E2 variants. The nucleotide

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