The Calcium Channel Blocker Gabapentin, a Benchmark Drug in Pain Studies, Inhibits Translocation of the Epsilon Isoform of Protein Kinase C in Cultured Nociceptors: A Novel Mechanism of Action

Gabapentin is a well-established anticonvulsant medication that is also beneficial in the treatment of pain associated with neuropathy. Gabapentin, a structural analogue of the gamma-aminobutyric acid inhibitory neurotransmitter, was first formulated as a third-generation antiepileptic drug in the early 1990s.

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