Hepatic Damage Induced by Griseofulvin as a Murine Model of Protoporphyia. Effect of Antioxidants | Chapter 5 | Innovations in Science and Technology Vol. 6

Erythropoietic Protoporphyria (EPP) is a condition defined by the buildup of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin due to ferrochelatase insufficiency. Severe hepatic failure and cholestasis were seen in some patients. In mice, griseofulvin (Gris) causes an

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