Phosphatidylinositol 3′ Kinase (PI3K), A Crucial Regulator of Epidermal Growth Factor Receptor (EGFR) Modulated MMP-2, MMP-9 and MT1-MMP Expression in Breast Cancer Cells

In breast cancer, tumour metastasis is responsible for the majority of mortality. Breast cancers with elevated epidermal growth factor receptor (EGFR) activity have been identified with increased tumour invasion and poorer prognosis. Increased expression of MMP-2, MMP-9 and MT1-MMP matrix

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All-trans Retinoic Acid (ATRA), a Potential Inhibitor of Matrix Metalloproteinase-2 (MMP-2) and Tumour Invasion in Melanomas

Increased expression and activity of matrix metalloproteinase-2 (MMP-2) has been correlated with an increase in invasive potential and a worse prognosis in many cancers including melanomas. The antitumorigenic potential of all-trans retinoic acid (ATRA) in melanomas was studied using the

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