Pimarane Diterpenes from Vietnamese Orthosiphon stamineus Benth. and Their Glucose Uptake Stimulatory and PTP1B Inhibitory Activities

From Orthosiphon stamineus Benth, seven pimarane diterpenes (1–7) have been isolated. By isolation by assay-guided. Both isolates had a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazole-4-yl)amino)-d-glucose absorption effect at 5 and 10 μM concentrations in 3T3-L1 adipocytes. Most of them demonstrated potent protein tyrosine phosphatase 1B

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