Synthesis of 4-Chloro-Piperidine Derivatives via NbCl5 Mediated Aza-Prins Type Cyclization of Epoxides and Homoallylic Amines

4-Chloropyperidine derivatives were synthesised under mild reaction conditions in good yield by reaction of epoxides and homoallylic amines using the Niobium pentachloride reagent. Author(s) Details Dr. Rajasekhar Koorella Ragas Pharmaceuticals Private Limited (OPC), IDA Cherlapally, Hyderabad, 500051, India. View Book

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Research on the Catalytic Hydrogenation of Substituted Pyridines with PtO2 Catalyst

Scientists are especially interested in the hydrogenation of substituted pyridines, because the resulting functionalized piperidines are the most important intermediates in the synthesis of both natural products and pharmaceuticals. The difficult methodology for the hydrogenation of substituted pyridines with a

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