Effect of Sodium Chloride Salts on Benzoic Acid Solubility and Dissociation into Water at 298 K

This study looked at the influence of sodium chloride (NaCl) salt concentration on benzoic acid (C6H5COOH) solubility and dissociation in water at 298 K temperature. Titrimetrically against a 0.05 M sodium hydroxide (NaOH) solution, the solubility of benzoic acid in

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Advanced Formulation Techniques to Enhance Solubility, Dissolution and Bioavailability of Poorly Water- Soluble Drugs

 The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. For a medicine to display maximum pharmacological response, this is considered a primary parameter. Poor aqueous-soluble drugs may have slow dissolving and

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Determining the Bulk Growth, Nucleation Kinetics, Optical and Spectral Analysis of Organic Nonlinear Material: 4-Chloroaniline (pCA) Single Crystal

The organic nonlinear optical material 4-chloroaniline was formed as a single crystal by slow cooling (pCA). The material solubility was determined via gravimetric analysis, and the metastable zonewidth MSZW was evaluated at various temperatures. For various supersaturation ratios and temperatures,

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Determining the Properties of Phenobarbital an Antiepileptic Drug Using Chemcalise Software

Barbiturate-class medications are used to treat some disorders, such as insomnia (difficulty sleeping), and to control certain seizures. Phenobarbital is an example of a medicinally important chemical. It's also renowned for its anticonvulsant, antidepressant, and antihypnotic properties [1]. Phenobarbital is

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Investigating the Enhancement of Solubility of Poorly Water-Soluble Drugs Diclofenac Sodium by Mixed Solvency Approach

Increasing solubility is one of the challenging issues that arises during the formulation development of an orally delivered medication with poor water solubility. Drugs with low water solubility have a difficult difficulty creating formulations with sufficient bioavailability, which prevents them

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Effect of pH on Benzoic Acid Solubilization and Its Partition in Water-Benzene Solvents

The solubility of a substance is determined by the solute-solvent interaction, pH, temperature, and ionic dissociation, among other factors, where the solute is partitioned between two immiscible liquid solvents. The solubility of benzoic acid (solute) as well as its partitioning

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Determination of a Linear Rule between the Osmotic Coefficients on Mole Fraction Base and Several Different Concentration Expressions in Single Electrolyte Solutions

In the paper, a linear rule between osmotic coefficients on mole fraction base and each of several concentration expressions is presented, respectively, in single electrolyte solutions containing various valence inorganic acids, alkalies, and salts, such as uniuni-, biuni-, triuni-, tetrauni-,

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Detailed Study on Synthesis, Characterization and Solubility Determination of 6-phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents

The synthesis, characterization, determination of solubility and solution thermodynamic properties of the cardiovascular drug 6-phenylpyridazine-3(2H)-one (PPD) in 12 different pharmaceutical solvents is proposed for this analysis at temperatures 'T = 298.2-318.2 K' and pressure 'p = 0.1 MPa.' The calculated

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