A Mechanistic Insight into Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

This study provides a mechanistic understanding of the oxidative degradation of favipiravir by electrogenerated superoxide via proton-coupled electron transfer. The oxidative degradation of pyrazine antiviral drugs, 3-hydroxypyrazine-2-carboxamide (T-1105) and 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir, T-705), by the electrogenerated superoxide radical anion was investigated

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A Mechanistic Insight into Superoxide Elimination by Mesalazine through Proton-Coupled Electron Transfer

This study elucidates a molecular understanding of how 5-amino-2-hydroxybenzoic acid eliminates the superoxide radical anion (O2•) (mesalazine, 5-ASA). Using cyclic voltammetry and electron spin resonance (ESR) investigations supplemented by density functional theory (DFT) calculations, the removal of O2• by 5-ASA,

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